WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

METHOD DEVELOPMENT AND VALIDATION OF TRAZODONE HYDROCHLORIDE BY RP- HPLC

J Subba Rao*, R Rambabu, S Vidyadhara, D Jaswanth Ram

ABSTRACT

Simple, accurate, precise and a new reversed-phase high performance liquid chromatographic (RP-HPLC) method has been developed and validated for the estimation of trazodone in pure and dosage forms. The proposed method is based on the separation of the reversed-phase mode using kromasil 100-5C18 Column  250mm × 4.6mm. The optimized mobile phase consisted of acetonitrile: methanol: water in the ratio 40:40:20 v/v, flow rate was set at 1.0 ml/min and UV detection was set at 255 nm. The average retention time was 2.34±0.003mins for trazodone. The method was validated according to ICH guidelines. It was found to be accurate and reproducible. Linearity was obtained in the concentration range of 20-100μg/ml. Percent recovery of sample was found to be 97.65%. The proposed method can be successfully applied in the quality control of bulk and pharmaceutical dosage forms.

Keywords: Trazodone, RP-HPLC, method validation,estimation, methanol and water.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More