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Dr. Naveen Poojar C M*, Dr. Basavaraj Bhandare


Background: Antimicrobial agents (AMAs) form an important aspect of ICU either for prevention or control of infections, as critically ill patients are more susceptible for infection due to immobilization, invasive procedures, (i.e., ventilators, catheters, etc.), compromised immune status and exposure to cross infections. Objectives: To evaluate the pattern and Criteria for selection of AMA’s used in ICU and to identify any adverse drug reactions, related to the AMA’s administered. Methods: A Prospective, observational study was conducted in 300 patients admitted Medical Intensive Care Unit at Rajarajeswari Medical college and Hospital. Data was collected from case records of patients admitted in ICU in a preformed proforma. Results: Respiratory tract infection (42%) was the most common reason for ICU admission. Ceftriaxone (52%) was the preferred AMA followed Amoxicillin+Clavulinic acid (34%). Amoxcillin + Clavulinic acid + Gentamycin (16%) was most commonly used drug combination. Only 1% of the patients got single antimicrobial therapy where as 3 drug combination in 55% and 4 drug combination in 26% and even 5 drug combination in 3% of the patients. Conclusion: This Study shows multiple drug combination therapy being widely used which is irrational.

Keywords: Antimicrobial agent, ICU, Infection.

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