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K.Divya, K.Kamala, .Venkataswamy and K. Thyaga Raju*


Acrylamide is carcinogenic to experimental animals, causing tumors at multiple organ and chromosomal sites in mice, rat and chick embryo when given in drinking water or by other means. The level of genetic integrity of human populations is increasingly under threat due to industrial activities that result in exposure to chemical and physical xenotoxins. The excess concentration of chemicals can cause damage to defence system and modifies tissue to lead to cancer. To encounter the above changes, the organisms are well equipped with certain defence enzymes like superoxide dismutase, catalase, peroxidases, glutathione S- transferases, mixed function oxygenase etc. These enzymes can participate either to catabolise or excrete the molecules from the body. Some of these enzymes are induced for secondary defence by using glutathione as primary substrate and the other chemicals as secondary substrates. The present study was focused on effect of glutathione (GSH; 0.1mg), the variable concentrations of acrylamide and combination exposure of acrylamide and GSH (Glutathione) on chick embryo liver for different time intervals i.e. 96hrs, 120hrs and 144hrs has indicated that acrylamide administration significantly increases damage in the antioxidant system with increased levels of time intervals (P< 0.05), However it has been observed that glutathione addition might protect the system from damage. The MDA content has been decreased in chick embryo liver due to the glutathione effect. With 0.025mg GSH 14.8, 6.51, 5.73 fold decrease, with 0.05mg GSH 7.45, 5.87, 4.43 and with 0.075mg 2.12, 1.92, 1.79 fold decrease has been observed at 96hrs, 120hrs and 144hrs. Glutathione by itself has enhanced the viability rate of chick embryo 75% in the presence of 0.1mg in vivo supply in the form of injection, because of decrease of MDA content in 2.125, 1.92 and 1.79 folds in the time intervals of 96hrs, 120hrs and 144 hrs respectively. In addition to these the antioxidant enzyme activities were found to be reduced less in liver by GSH compared to acrylamide treatment to chick embryos.

Keywords: Acrylamide, GSH, Lipid peroxidation, Chick embryo liver, Antioxidants.

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