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Abstract

FORMULATION AND EVALUATION OF BIOADHESIVE BUCCAL TABLETS OF MOSAPRIDE CITRATE

Ramya Sri Sura* and S. Pavani

ABSTRACT

The objective of the present study was to develop bioadhesive buccal tablets of Mosapride Citrate so as to avoid it from first pass metabolism. Different grades of HPMC polymers, Carbopol 934 intended for buccal tablet formulation for selected and studied for their comparative mucoadhesive force, swelling behavior, residence time and surface pH. The preformulation study was performed by FTIR spectroscopy and it was revealed the compatibility of drug and polymer. Ex vivo permeation study of Mosapride Citrate pure drug solution through the porcine buccal mucosa was performed and the flux value was found to be 424.735μg.hr-1cm-2 The mucoadhesive tablets were prepared by direct compression method. The tablets were evaluated for pre-compression parameters, thickness, hardness, weight uniformity, content uniformity, surface pH, swelling index, in vitro drug release, ex vivo residence time, bioadhesion strength, ex vivo permeation. In vitro assembly was used to measure the bioadhesive strength of tablets with fresh porcine buccal mucosa as model tissue. The tablets were evaluated for in vitro release in pH 6.8 phosphate buffer for 8 hrs in standard dissolution apparatus. The pre-compression parameters were in acceptable range of pharmacopoeial specification. The surface pH of the selected formulations was in the range of salivary pH and showed ex vivo residence time indicated good adhesive capacity of selected formulations. Among various selected formulations F11 formulation containing combination of HPMC K15M and Carbopol 934 in the ratio of 1:1 showed maximum percentage drug release i.e., 94.9% in 8 hrs with good ex vivo residence time, maximum flux and permeability coefficient values i.e., 8 hrs 5 min, 418.445 μg.hr-1cm-2 and 0.4122 (cm/hr). The formulation F11 was followed Korsmeyer peppas mechanism with Regression value of 0.9829 and n value was found to be 0.6154, it indicates that it follows non fickian drug release pattern.

Keywords: Buccal tablets, Mosapride Citrate, Bioadhesive polymers, Flux, Permeability coefficient.


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