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Abstract

A VALIDATED RP-HPLC METHOD FOR THE SIMULTANEOUS DETERMINATION OF LEVODOPA, CARBIDOPA AND ENTACAPONE IN TABLET DOSAGE FORMS

Gandla. Kumara Swamy*, JM Rajendra Kumar , J.V.L.N.Seshagiri Rao

ABSTRACT

A Stability indicating RP-HPLC method has been developed for the
simultaneous estimation of Levodopa, Carbidopa and Entacapone in
tablet dosage forms using an RP- Hypersil BDS column (150 x 4.6
mm; 5). A mobile phase consisting of Potassium Dihydrogen
orthophosphate and Acetonitrile in the ratio of 95:5.0 was pumped
through the column at a flow rate of 1.0 mL/min. The separations of
drugs were monitored at 280 nm. Linearities of quantification were
observed in the concentration range of 75–225 μg/ml for Levodopa,
18.75-56.25 μg/ml for Carbidopa and 100 -300 μg/ml for Entacapone.
The method was duly validated. A%RSD of less than 2% indicates the
high degree of accuracy and precision of the method. Due to its high
precision and accuracy, the proposed Stability indicating RP-HPLC
method can be applied for determining Levodopa, Carbidopa and
Entacapone simultaneously in bulk and Combined Tablet dosage
forms.

Keywords: Levodopa, Carbidopa and Entacapone; RP-HPLC Method; Forced Degradation studies; Tablet dosage forms.


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