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Abstract

“HÉMODYA”: A PHYTOMEDECINE FOR SICKLE CELL DISEASE MANAGEMENT IN CAMEROON

Agbor A. G.; Kotué T. C.; *; Mouotsouo J. P.; Nanfack P.; Nkam M.;Ngogang Y. J.

ABSTRACT

The present study, evaluates the role of “hémodya” as a phytomedicine in the management of sickle cell disease. The phenolic content, free radical, and reactive oxygen scavenging ability of “hémodya” were measured. The quality of hémodya’s antioxidant was evaluated in the prevention of LDL oxidation in vitro. Blood samples of sickle cell patients were incubated with “hémodya” for one hour to study the migration of membrane and plasma lipids. “Hémodya” showed some antioxidant capacity by scavenging free radicals and reactive oxygen species in vitro. “Hémodya” was also effective than alpha tocopherol in preventing the oxidation of low-density lipoprotein cholesterol (LDL-c). “Hémodya” reducing the rigidity of the erythrocyte by reducing its cholesterol content. That antioxidant activity of “hémodya” may be applicable in the reduction of oxidative stress posed to the lipids during sickling crises.

Keywords: “Hémodya”, heamoglobin, membrane lipids, reactive oxygen species, Sickle cell disease, phenolics.


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