FLUOROQUINOLONE ANTIBIOTIC (ENROFLOXACIN) METAL COMPLEXES: SYNTHESIS, SPECTROSCOPIC AND IN VITRO ANTIMICROBIAL SCREENING PROPERTIES
Nadia E.A. El-Gamel*, M.A.Zayed
ABSTRACT
Complexes of the antibiotic gyrase inhibitor enrofloxacin (HL1) with
the transition metals Cu (II) (1), Mn (II) (2), Cr (III) (3), and Fe (III)
(4) and in a mixed complex with dl-alanine (H2L2) with Cu (II) (5), Mn
(II) (6), Cr (III) (7), and Fe (III) (8) were synthesized and their antibacterial
activity (Staphylococcus aureus, Escherichia coli) and antifungal
potential (Aspergillus flavus and candida albicans) was
investigated in vitro. The complexes were characterized with elemental
analysis, IR-and UV-Vis spectroscopy. Geometry and structural
properties of the complexes were deduced from the magnetic
susceptibility, measurements of the molar conductivity and from
simultaneous measurements of thermal mass loss (TG) and differential
thermal analysis (DTA). All complexes form chelates with planar (1) or distorted octahedral
(2) - (8) geometry as indicated by spectroscopic measurements and calculations of the molar
magnetic susceptibility m. Antibiotic in vitro assay screening showed a significant antibacterial
and anti-fungal activity for the complexes Cu (II) (5) and Mn (II) (6), much higher
compared with the other complexes and the pure enrofloxacin.
Keywords: Enrofloxacin, metal complexes, spectroscopic studies, simultaneous thermal analysis (TG/DTA), antimicrobial activity.
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