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Abstract

THE PATHOPHYSIOLOGICAL EFFECTS OF SERUM COPPER IN TYPE 2 DIABETES MELLITUS WITH AND WITHOUT DIABETIC NEPHROPATHY

Mohammed A. Al-Bayati,  Dina A. Jamil,  Hayder A. Al-Aubaidy

ABSTRACT

This study was undertaken to investigate the effects of copper on the development of lipid peroxidation in patients with type 2 diabetes mellitus with and without diabetic nephropathy. Fifty-five patients with type 2 diabetes mellitus were recruited in this study and were divided into 2 sub-groups based on the presence of microalbuminuria, the first group (microalbuminuric group n=31) had a microalbuminuria between 30-299 ug/mg. The second group (normoalbuminuric group, n=29) had an albumin level less than 30 ug/mg. The two diabetic groups were compared to the control group (n=37). The results of our study showed significant elevation in the levels of serum lipid profiles and lipid peroxidation markers in the microalbuminuric group compared to the normoalbuminuric group at P<0.001. This was associated with significant rise of serum copper in the diabetic group with nephropathy compared to the diabetic group with no nephropathy and the control group, P<0.001. The current study illustrates that the presence of microalbuminuria in type 2 DM can be regarded as an index of increased cardiovascular vulnerability and a signal for vigorous efforts at correction of known modifiable risk factors in which serum Cu one of them.

Keywords: Serum copper, lipid peroxidation, microalbuminuria, type 2 diabetes mellitus


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