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Abstract

POTENTIAL BIOLOGICAL EVALUATION OF HYPOGLYCEMIC ACTIVITY OF LEAVES OF AGANOSMA DICHOTOMA

Md. Zahirul Islam Khan, Md. Reyad-ul-Ferdous*, Md. Iftekhar Hussain, Md. Atiqul Islam, Jakia Sultana, Md. Naimul Islam, Subash Pandaya, Manson Pandey

ABSTRACT

The hypoglycemic effects of methanolic extract of Aganosma
dichotoma were prepared from its leaves which were examined in
Swiss-albino mice for conducting the experimental study. In doses of
200 and 400 mg/kg body weight of Aganosma dichotoma were used to
compare with its standard Glibenclamide dose of 10 mg/kg body
weight. Both doses of 200 and 400 mg/kg lowered the plasma glucose
statistically significant level in 3 hours administration with its standard
drug Glibenclamide. From this study it has been concluded that the
methanolic extract of leaf of Aganosma dichotoma having good
hypoglycemic effect and increase in plasma insulin concentration.

Keywords: Aganosma dichotoma; Glibenclamide, Leaf extracts, Hypoglycemic activity.


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