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Abstract

IN VITRO ANTIDERMATOPHYTIC ACTIVITY OF ALLIUM SATIVUM L, NICOTINA TABACUM AND CADE OIL AGAINST TRICHOPHYTON RUBRUM

A. Aiboud*, A. Moussaif, N. El Abbadi, A. Ettabia, A. El hessni, A. Ouichou, M. Chakit and A. Mesfioui

ABSTRACT

Onychomycosis is a disease that affects mainly the nails of the feet. It
is caused by different fungi especially dermatophytes whose
Trichophyton rubrum is the main cause in 80% of cases. The purpose
of our study is to test the antifungal activity in vitro of different
extracts of Allium sativum L, Nicotina tabacum and Oil of Cade
usually used in traditional medicine for the treatment of skin disease in
Morocco. The Minimum Inhibitory Concentration (MIC) was
determined using a broth microdilution method and determined
spectrophotometrically at 530 nm. T.rubrum has shown sensitivity
against the various extracts of Allium sativum L, Nicotina tabacum and
Cade Oil. The Nicotina tabacum extracts have shown the best inhibitor
effect whose MICs were 0.1 μg / ml for hexanilic and chloroformic
extract and 2μg/ml for the ethyl acetate extract followed by Allium sativum L whose the
MICs were 10 μg / ml for the chloroformic extract and 100 μg / ml for hexanilic and ethyl
acetate extracts. For the Cade Oil the MICs were 100 μg / ml for liquid phase washed with
hexane and the liquid phase washed with water while the MIC was 40 μg / ml for the extract
of water washing. Nicotina tabacum has shown the best antifungal activity against T.rubrum
followed by Allium sativum L and Cade Oil also. The chloroformic extract was the most
active in comparison with hexane and ethyl acetate extracts.

Keywords: Dermatophytes; Trichophyton rubrum ; Allium sativum L; Nicotina tabacum; Cade Oil; Minimal Inhibitory Concentration.


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