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Abstract

EVALUATION OF HEPATITIS B SURFACE ANTIGEN SECRETION INHIBITION AND HEPATOPROTECTIVITY BY HEP-02, AN HERBAL FORMULATION

Dr. Sweta T Kothari*, Devanshi Gohil, Dr. Zaiba Shaikh, Dr. Milind Patil,Dr. Abhay Chowdhary

ABSTRACT

Hepatitis B virus (HBV) infects around 350 million of the global
population. The current antivirals are laden with side effects as well as
expense burden. An alternative medication based on Ayurveda is being
proposed to counter this scenario. HEP – 02 is a herbal formulation
used for the treatment of hepatitis B virus. It is also indicated for
alleviation of hepatotoxicity. The molecular mechanism involved in
the anti-HBV activity of this formulation is being studied using in-vitro
models for the first time. Inhibition of Hepatitis B surface antigen
(HBsAg) secretion from the transfected human hepatocarcinoma
PLC/PRF/5 cells, as well as inhibition of the surface antigen binding
was taken up in the present study. Suppression of HBsAg production
and inhibition were best observed at 150μg/mL and this concentration was used to determine
the hepatoprotectivity in a Kupffer cell-hepatocyte in-vitro co-culture, determined by the
expression of cytokines TNF-α, IL-6 and IL-10, in presence of bacterial lipopolysaccharide.
The results indicate that HEP-02 could thus be beneficial in the treatment of liver
inflammation in Hepatitis B.

Keywords: HEP-02, HBsAg secretion, Kupffer cells, LPS, inflammation, hepatoprotectivity.


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