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Abstract

INFLUENCE OF ESTRADIOL VALERATE (PROGYNOVA) ON AGED FEMALE ALBINO RATS WITH REFERENCE TO CARBOHYDRATE METABOLITES

Lalithamma A & Changamma C*

ABSTRACT

The present study was designed to evaluate the efficacy of estradiol valerate on glucose and glycogen in aged female albino rat tissues. Wistar strain albino rats at 20 months age group were administered with estradiol valerate at dose 8mg/Kg body weight/day orally for one week. The glucose and glycogen levels were estimated in young, aged and aged administered with estradiol valerate. The administration revert the glucose levels in ovary, no changes in uterus, and in vagina further depletion of glucose takes place. Aging does not altered glucose levels in heart and liver but estradiol valerate administration slightly increased as estrogens mobilizes glucose levels. After administration glycogen levels were regained in ovary. Elevated glycogen levels in heart have been shown to have cardio protective effects. The liver glycogen storage capacity was diminished in aged rats and elevated by the administration.

Keywords: Menopause, Estradiol valerate, Glucose, Glycogen.


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