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Abstract

ANTI-TUMOR ACTIVITY OF FRUIT EXTRACTS OF MOMORDICA DIOICA ROXB.

Revathy Sivan, Bhavana V, Krishna KL*, Mahalakshmi AM,
Ramprasad KL, Tekuri Manoj Kumar.

ABSTRACT

Various parts of Momordica dioica roxb. (MDR) have been traditionally used as ethnomedicine for a number of disorders. The aim of the present study was to examine the antitumor effect of various extracts of MDR fruits on DLA induced tumour models in mice. The crude chloroform and methanolic extract were prepared by soxhlet extraction. The marc remained after methanolic extraction was macerated with chloroform water (5:95) to yield the aqueous extract. All the three extracts were evaluated for their in vitro antioxidant and in vitro antitumor activity to select the promising ones. The promising extracts were then subjected for in vivo anti tumour activity against DLA induced tumour model using swiss albino mice. Cyclophosphamide was used as the standard anticancer agent. Methanolic and chloroform extract showed best antioxidant and free radical scavenging activity owing to their high phenolic content. Chloroform extract has shown maximum activity on in vitro anti cancer activity among all three extracts. The activity was found to be significant and more for chloroform extract than methanolic extract. This may be due to chloroform soluble phytochemical may possess good antitumor activity. These results suggest that MDR fruit extracts possess strong antioxidant and anti tumour activity against the transplantable tumour models. However, further studies are required to support the assumption.

Keywords: Momordica dioica, Anti-tumour, DLA, Brain shrimp, Solid tumor.


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