WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

GENOTOXICITY AND ADVERSE HUMAN HEALTH OUTCOMES AMONG PEOPLE LIVING NEAR HIGHLY POLLUTED WASTE WATER DRAINS IN PUNJAB, INDIA

Dr. J S Thakur*, Dr. Shankar Prinja, Prof. Dalbir Singh, Prof. Arvind Rajwanshi, Dr. Sunil Arora, Prof. Rajendra Prasad, Dr. Harjinder Kaur Parwana, Prof. Rajesh Kumar

ABSTRACT

Background: Depleting water resources, industrialization and rampant use of pesticides and fertilizers in agriculture has led to pollution of water bodies in Punjab. This is associated with acute and chronic morbidities among humans. Objectives: To ascertain the pattern and extent of water pollution and determine association if any between exposure to water pollution and adverse human health. Methods: A cross sectional study was done among 5567 and 2289 persons selected in reference and control area. Effluent, ground and surface water samples along with fodder, vegetable, milk (bovine and human), blood and urine samples were tested to ascertain effects of heavy metal and pesticide pollution of water bodies. Genotoxicity was assessed by micronucleus assay and DNA adduct studies. Results: Gastrointestinal, water-related, eye, skin and bone diseases were significantly associated among reference area population (p<0.05). Higher prevalence of micronuclei was observed among reference area population while 40% and 10% were having evidence of moderate and high mutation respectively. Mercury, lead, chromium, cadmium and selenium were found in more than permissible limits (MPL) in ground and surface water. Chlorpyriphos, β-endosulphan, dimethoate, heptachlor and α-endosulphan were found in samples of effluent and ground water exceeding MPL. Heavy metals and pesticides were also detectable in fodder, vegetable, milk, urine and blood samples. Conclusion: There were significantly higher systemic and general health morbidities along with manifestations of genotoxic effect possibly due to heavy metal and pesticide contamination of water bodies. . Stringent monitoring of water quality and specific DNA adduct study is required.

Keywords: .


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More