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Abstract

PHARMACOKINETIC ANALYSIS USING SAS®: A BOON FOR CLINICAL RESEARCH INDUSTRY

Abhimanyu Thakur* and Srijani Chatterjee

ABSTRACT

Pharmacokinetics (PK) is the study of fate of drug after its administration to the subject which involves studies of the absorption, distribution, metabolism and elimination (ADME) in human or animal though their body fluids (blood or urine). A single pharmacokinetic profile encompasses Cmax, Tmax, t1/2, AUC, etc. In a clinical research study, a large number of data are collected from the subjects during clinical trial. The data may be from different sources and it may be in different format. Hence, their retrieval, storage and analysis is a major concern in a Clinical Research Organization (CRO). To deal with those data so as to determine the pharmacokinetic parameters an authentic, validated, reliable and suitable system is required and as per the prevailing reviews SAS® proves to be the best example. In this paper an attempt has been made to present the use of SAS® software for pharmacokinetic analysis.

Keywords: SAS®, Pharmacokinetic analysis, clinical research, clinical trial.


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