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Abstract

KINETIC ANALYSIS OF OXIDATION OF OFLOXACIN BY PERMANGANATE ION IN SULPHURIC ACID MEDIUM: A MECHANISTIC APPROACH

Vijay Devra, Ankita Jain, Shikha Jain

ABSTRACT

The kinetics and mechanism of oxidation of ofloxacin by permanganate ion in acidic medium have been studied at 30 ±1oC. The Stoichiometry has been observed to be 2:5 in terms of mole ratio of permanganate ion and ofloxacin consumed. The reaction shows first order with respect to oxidant and fractional order in both the substrate and hydrogen ion concentration. The effect of added products and ionic strength has also been investigated. The main products identified were 7-amino quinolone and Mn(II). Investigation of the reaction at different temperature allowed the determination of the activation parameters with respect to the slow step of the proposed mechanism.

Keywords: Kinetics, Oxidation, Mechanism, Ofloxacin, Permanganate ion, Sulphuric acid medium.


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