WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60


Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here


Track Your Article



Mukesh Sharma*, Kirti Parmar, Atul Baria, Tushar M. Patel, Rohan Lalani, Rajesh K Parikh


Present work highlights a strategy to develop a hydrophilic matrix based sustained release formulation for gastro-retentive drug delivery system (GRDDS) of Febuxostat. GRDDS is realized as a promising option for gout treatment, as the delivery system can control and prolong gastric residence time and supply high drug concentration in gastric region for better action. Swellable and floatable gastroretentive tablets were prepared by direct compression technique and evaluated for their swelling characteristics (Swelling index, water uptake), floating capacity (floating lag time and duration), Invitro drug release and stability studies. Factorial design was employed to optimize formulation components. Nine formulations were prepared using two independent variables, amount of Hydroxy Propyl Methyl Cellulose (HPMC) K4M (60, 90, & 120 mg) and amount of Sodium bicarbonate (20, 30, & 40 mg). The floating lag time and time required for 90% (t90%) of drug release were selected as dependent variables. Optimized formulation showed zero order Invitro drug release for more than 10 hours with excellent buoyancy properties. The prepared tablets floated within 3 min and maintain for more than 18 h. The decrease in the release rate was observed with an increase in the viscosity of the polymeric system. Polymer with lower viscosity (HPMC K4M) was shown to be beneficial than higher viscosity polymer (K15M and K100M) in improving the floating properties of GRDDS. These results suggest that prepared GRDDS has the improved release and retentive properties which will be translated into better treatment for gout and other disease.

Keywords: Febuxostat, floating and swelling properties, HPMC, Sodium Bicarbonate, In vitro release, Factorial design.

[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More