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Abstract

PREPARATION & FORMULATION OF POLYHERBAL OINTMENT FOR WOUND HEALING ACTIVITY

*Santosh M. Kurbetti , Ansar M. Patel, Dr.R.M.Chimkode, G.Derkar,
DR. S. S. PATIL

ABSTRACT

Aim:- The present study aimed to moderate the wound healing activity of polyherbal plants like Erythrina indica leaf, Calatropsis procera root & Ficus religiosa bark in topical ointment formulation. Method:- The emulsifying ointment formulations containing extracts of the exceeding mentioned herb was formulated, evaluated and their wound healing activity was studied on experimentally induced excision open wounds in albino rats. Result:- The effects of the formulation on wound healing were assessed by the rate of wound closure, period of epithelialization. The methanol extract(by hot extraction process) of Erythrina indica leaf, Calatropsis procera root & Ficus religiosa bark 2%, 4%, & 5% is incorporated into 100 g. of a simple ointment base by melting and triturating method for preparation of polyherbal ointment formulation. The measurement of the wound areas were taken up-to 18th days and the percentages of wound closures were calculated. Blank ointment base and Framycetin ointment (1% w/w) served as the control and standard treatments. Topical application of 5% Erythrina indica leaf, Calatropsis procera root & Ficus religiosa bark of the prepared ointment on the excision wound in rats caused a significantly (p<0.05) higher rate of wound healing and reduced the epithelialization period in a dose-related approach. The polyherbal ointment treated group showed complete epithelialization is compared to the (1%) Framycetin ointment. The formulated ointments were evaluated and effective in wound care and should be explored in harnessing the potentials of the plant in the treatment of Topical diseases.

Keywords: Wound healing, Polyherbal formulation, Excision wound.


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