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Pradip Nehe*, K.S.Salunkhe, S.R. Chaudhari, P.B.Gadge, G.S.Dighe, Amit Asati


The main objective of this study is to develop a new solid self-nano emulsifying drug delivery system (SNEDDS) for oral poorly watersoluble drugs. S-SNEDDS are alternatives of conventional liquid SNEDDS and also are superior in reducing production cost, simplifying industrial manufacture, and improving stability as well as patient compliance. The solid SNEDDS prepared by solidification of liquid/semisolid self nano emulsifying ingredients into powder, using different solidification technique is (spray-drying, adsorption on solid carrier, melt granulation, melt extrusion so on.) to improve the oral bioavailability of poorly water-soluble drug. Conversion of liquid SNEDDS to powder form using different solid carrier. The liquid SNEDDS are formulated by utilizing an oil phase, surfactant and a cosurfactant. This formulation forms nano emulsion (O/W type) on Contact with aqueous body fluids i.e. gastric juices when administered orally. The prepared formulation were evaluated for self emulsification time, dispersibility study, average globule size, Polydispersibility index (PDI). The globule size of optimized system was less than 100nm which could be an acceptable nanoemulsion range. Solid state characterization of the solid SNEDDS was performed by SEM, DSC, and X-ray powder diffraction.

Keywords: Solid-Self nanoemulsifying drug delivery system (S-SNEDDS), oil phase, surfactants, co surfactants, Adsorbants, Pseudo ternary phase diagrams.

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