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Abstract

DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR THE ESTIMATION OF QUINAPRIL HYDROCHLORIDE IN BULK AND IN ITS FORMULATION

Mali Audumbar*, Jadhav Santosh, Tamboli Ashpak, Bathe Ritesh, Patil Manoj

ABSTRACT

A simple, precise and accurate difference spectroscopic method has been developed for the estimation of Quinapril Hydrochloride in bulk drug form by difference spectrophotometric method. Quinapril Hydrochloride has exhibited maximum absorbance at about 207nm and 222nm in acidic and basic solution respectively. Beer’s law was obeyed in the concentration range of 2-10 μg/ml in both the cases. The regression of coefficient was found to be r2=0.996. The LOD and LOQ value were found to be 0.766 ppm and 2.324 ppm respectively. The proposed method was successfully applied for the determination of Quinapril Hydrochloride in bulk drug. As per ICH guidelines the result of the analysis were validated statistically and were found to be satisfactory.

Keywords: Quinapril Hydrochloride, Validation, Hypertension, Spectrophotometer.


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