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Abstract

BILAYER TABLET-TECHNOLOGY- A REVIEW

Gajanan Venkatrao Pulgamwar*, Ram S. Pentewar, Rohit U. Bharti, B. K. Sugave and Saroja P. Adepawar

ABSTRACT

Several pharmaceutical companies are currently developing bi-layer tablets, for a variety of reasons: patent extension, therapeutic, marketing to name a few. Bi-layer tablet is a new era for the successful development of controlled release formulation along with various features to provide a way of successful drug delivery system and it is suitable for sequential release of two drugs in combination, separate two incompatible substances and also for sustained release tablet in which one layer is immediate release as initial dose and second layer is maintenance dose. Bi-layer tablets can be primary option to avoid chemical incompatibilities between APIs by physical separation and to enable the development of different drug release profiles. The present article provides a review on the oral drug delivery system, types of tablets, Bilayer tablet manufacturing, various tablet presses used, quality and GMP requirements for high production output and recent developments in the field of Bilayer technology and why development and production of quality bi-layer tablets need to be carried out on purpose built tablet presses to conquer common Bilayer problems, such as layer separation, insufficient hardness, inaccurate individual layer weight control, cross contamination between the layers, reduced yield.

Keywords: Bi-layer tablet, Approaches, GMP requirement for bi-layer tablets, various tablet presses.


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