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Abstract

THE AMELIORATIVE EFFECT OF CARROT PECTIN AGAINST LEAD ACETATE INDUCED RENAL AND HEPATIC TOXICITY IN RATS: BIOCHEMICAL AND HISTOPATHOLOGICAL STUDY

Ouardia Ouldali1,2, A. Aoues2, B. Meddah1, O. Kharoubi 2

1Department of Biology, Laboratory for Research on Biological Systems and Geomatics, Faculty of Nature and Life Sciences, University of Mascara, Algeria
2Department of Biology, Laboratory of Experimental Biotoxicology, Biodepollution and Phytoremediation, Es-Senia University, Oran, Algeria.

ABSTRACT

Background: Poisoning resulting by the ingestion of lead containing products is an important toxicological concept in pediatric age group. Aims: In sub-acute lead poisoning, decontamination options as curative treatments are limited in efficacy. This two steps study is used to show the effects of pectin, which is a natural adsorbent on the chelation of lead and the reduction of the toxic effect in rats. Methods and Materials: The adverse effects of lead toxicity were observed on liver and kidney, more precisely, the increased activity of transaminases and the renal markers. Urea and creatinine have been demonstrated after one month of oral lead administration. Statistical analysis used: To compare the different experimental groups, analysis of variance (ANOVA) was used following post hoc Tukey's test. The level of significance between the groups was set at P<0.05. Results and Conclusions: The addition of carrot pectin at 3%, in the feeding of intoxicated rats, showed chelating and correcting effects on liver and kidney disturbances that were caused by lead toxicity. The findings of the present study suggest that the possible oxidative stress and histopathological abnormalities induced by lead can be neutralized by pectin in the lead exposed population.

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