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Mukhtar Ahmad Dar, Sarita Shrivastava and Prince Firdoos Iqbal


Click chemistry is a modular synthetic approach towards certain organic reactions; with features of rapidity, simple utility, easy purification, versatility, regiospecificity and productivity (in terms of yield). The ever increasing demand for novel biologically active compounds and the arduous processes of lead discovery and optimization have resulted in the continuous search for the strategies that can pave way to simple and efficient methods. Click chemistry is a result of this exhaustive and extensive search. Triazoles can easily be synthesized through click chemistry and readily interact with biological targets through hydrogen bonding and dipole interactions. The triazole nucleus is present as an important moiety in an array of drug categories such as anti-microbial, anti-inflammatory, analgesic, anti-peptic, anti-viral, anti-neoplastic, antitubercular, anti-parkinsons, anti-diabetic, anti-depressant etc. The broad and the potent activity of triazoles and their derivatives have established them as pharmacologically significant scaffolds. The present review is an attempt to showcase the anti-cancer activities of 1,2,3-triazole derivatives developed mainly through click chemistry approach.

Keywords: Click chemistry,1,2,3-triazoles, cycloaddition, anti-cancer activities.

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