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Mohammad Shahriar*, Nazma Akter Tithi, Rumana Akhter, Sonia Kamal, Syeda Najah Narjish and Mohiuddin Ahmed Bhuiyan


Typhonium trilobatum (L.) Schott of the family Aracae has been considered as an important plant in traditional medicine practices in Bangladesh. The aim of the present study was to evaluate the phytochemical constituents of Typhonium trilobatum along with invitro antioxidant activity, in-vitro thrombolytic and membrane stabilizing activities, in-vivo anti-spasmodic activity, in-vivo antidepressant activity and acute toxicity were investigated. Standard qualitative chemical tests were performed as phytochemical screening and the presence of flavonoids, phenols, and alkaloids was detected in various parts of the plant. Six different assays were performed to evaluate antioxidant activity and the leaf extracts showed good potential. The presence of flavonoid and phenolic contents was remarkable in the ethanolic leaf extract of the plant. Methanol (% clot lysis 30.15%) and chloroform (% clot lysis 22.64%) extracts of leaves of the plant showed significant (p<0.05) thrombolytic effect and good human RBC membrane stabilizing effect. Chloroform extracts of 200 mg/kg showed very significant (p<0.01) result in GI motility. All the leaf extracts of 100 and 200 mg/kg demonstrated very potent dose dependent anti-depressant effect. Thus the present study validated the traditional uses of Typhonium trilobatum and demonstrated its potential to contribute in drug discovery from natural resources.

Keywords: Typhonium trilobatum, Membrane stabilizing, in-vitro antioxidant activity, GI Motility, Acute Toxicity.

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