EFFECT OF MUCUNA PRURIENS ON BIOCHEMICAL AND HAEMATOLOGICAL PARAMETERS IN MPTP INDUCED MICE
Uma S*, G. Ariharasivakumar, Tamilarasan M and P. Gurumoorthi
ABSTRACT
Mucuna pruriens has been known to possess valuable medicinal
properties. The present study aims at investigating the effects of M.
pruriens seeds against1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine
(MPTP) induced mice on haematological and bio-chemical parameters.
Male Swiss albino(Groups=7) mice with weights ranging from 25 to 30
g were fed with different concentration (200mg/kg, 400mg/kg) of M.
pruriens seeds for one week. The result shows that the seeds improved
the haematological and serum biochemical parameters with dosedependent
manner in MPTP induced mice. The effect of methanolic seed
extract of M. pruriens seeds on Aspartate aminotransferase (AST),
Alanine Aminotransferase (ALT) and Alkaline Phosphatase (ALP)
activities were evaluated using spectrophotometric method. The results
showed that the parameters of serum cholesterol, urea, creatinine, and
triglycerides were normalized when the treated mice when compared to
the control. In conclusion, the effect of biochemical and haematologic
parameters of Mucuna pruriens seed extract were observed in MPTP treated mice.
Keywords: Biochemical analysis, haematological parameters, Mucuna pruriens, 1-methyl- 4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP).
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