Abstract

EFFECT OF MUCUNA PRURIENS ON BIOCHEMICAL AND HAEMATOLOGICAL PARAMETERS IN MPTP INDUCED MICE

Uma S*, G. Ariharasivakumar, Tamilarasan M and P. Gurumoorthi

ABSTRACT

Mucuna pruriens has been known to possess valuable medicinal properties. The present study aims at investigating the effects of M. pruriens seeds against1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) induced mice on haematological and bio-chemical parameters. Male Swiss albino(Groups=7) mice with weights ranging from 25 to 30 g were fed with different concentration (200mg/kg, 400mg/kg) of M. pruriens seeds for one week. The result shows that the seeds improved the haematological and serum biochemical parameters with dosedependent manner in MPTP induced mice. The effect of methanolic seed extract of M. pruriens seeds on Aspartate aminotransferase (AST), Alanine Aminotransferase (ALT) and Alkaline Phosphatase (ALP) activities were evaluated using spectrophotometric method. The results showed that the parameters of serum cholesterol, urea, creatinine, and triglycerides were normalized when the treated mice when compared to the control. In conclusion, the effect of biochemical and haematologic parameters of Mucuna pruriens seed extract were observed in MPTP treated mice.

Keywords: Biochemical analysis, haematological parameters, Mucuna pruriens, 1-methyl- 4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP).