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Abstract

EVALUATION OF NARINGENIN ROLE IN INHIBITON OF LUNG TUMOR PROGRESSION IN MICE

Vishnu Varthan Jagannathan Vaithiyalingam*, Sathish kumar Natarajan Muthureddy, and Srividya Ammayappan Rajam

ABSTRACT

Naringenin, aglycone flavonoid possess certain activities like antioxidiant, anti-viral, anti- microbial, anti-allergic, anti-estrogenic, antidiabetic, cardioprotective, anti-obesity, anti-inflammatory, hepatoprotective and also have anti-cancer characteristics like carcinogenic inactivation, cell cycle arrest, anti-proliferation, apoptosis, anti-angiogenesis and enhances anti-oxidant activity. The inhibitory effect of Naringenin in lung tumor progression estimated with adenocarcinoma (A549) cell lines (in vitro) and C57BL/6 mice (in vivo) in a tri-dose manner compared with standard chemotherapy drug cisplatin. The results of the present study revealed, a dose-dependent activity in Naringenin and combination with cisplatin at a higher dose which showed decreased tumor progression in mice. Combination of Naringenin with cispaltin demonstrate beneficiaryaction than individual action. In vitro studies carried out for estimation of cell survivial and Nitric Oxide (NO) level shows dose dependent action of nringenin with IC50 value of 42μg/ml. In vivo studies was carried out in C57BL/6 mice. Naringenin satisfied the condition of an anti-cancer molecule with its characteristics in fragmentation assay, Zymography assay, anti-oxidant and myeloperoxidase studies, than cispaltin which failed in anti-oxidant and myeloperoxidase effect. Both in vitro and in vivo establishes dose dependent decrease in NO levels. But whereas Naringenin showed adverse results in Matrix Metalloproteinase (MMP) enzymatic levels with increase in dose levels. In conclusion Naringenin could suppress the lung tumor progression when given individually and also in combinatorial with standard chemotherapy drug.

Keywords: lung cancer, naringenin, cisplatin, Matrix metalloproteinase, myeloperosidase, Nitric oxide.


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