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Abstract

ETHANOLIC BRASSICA OLERACEAE ITALICA EXTRACT PRETREATMENT ALLEVIATES ISOPROTERENOL INDUCED OXIDATIVE MYOCARDIAL NECROSIS IN RATS

Gowri S*, Suganthi V, Dr.Gurusamy K

PG and Research Department of Biochemistry, Dr.N.G.P Arts and Science College, Coimbatore, India.

ABSTRACT

Ethanolic Brassica oleraceae italica extract (200 mg/kg) pretreatment for 30 days in Isoproterenol (ISO) treated rats significantly decreased the levels of myocardial marker enzymes (lactate dehydrogenase, creatine kinase, Transaminases), uric acid and increased myocardial lipid peroxides. Histological examination of ratís heart section confirmed myocardial injury with ISO administration and near normal pattern with ethanolic Brassica oleraceae italica extract pretreatment. The results of the present study for the first time provide clear evidence that the ethanolic Brassica oleraceae italica extract pretreatment enhances the antioxidant defense against ISO induced oxidative myocardial injury in rats and exhibit cardio protective property.

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