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Abstract

SYNTHESIS OF SOME MERCAPTO BENZOTHIAZOLE DERIVATIVE WITH THEIR CHARACTERIZATION AND BIOLOGICAL EVALUATION

Ashish Asrondkar*, Vrushali Patil, Neha Mishra, Anil S. Bobade and A. S. Chowdhary

ABSTRACT

In present study we synthesized some 2-amino mercapto benzothiazole and Acid Chloride derivatives and screen synthesized compounds for their anti-microbial activity. 2-amino mercapto benzothiazole on reacting with ethyl chloro acetate forms ester derivative of benzothiazole which on further treatment of hydrazine hydrate formed hydrazino derivatives of mercaptobenzothiazole, It was then treated with carbon disulphide to form oxadiazole derivative of mercapto benzothiazole and finally it was condensed with different substituted Acid chloride to form final compound. Synthesized compounds have been confirmed on the basis of spectral studies by using FT-IR, NMR, Mass Spectrophotometer. All the compounds were screened for their in vitro anti-inflammatory, in vitro anti oxidant and in vitro antibacterial activity against E. coli, S. typhi, P. aeroginosa, Kleb pneumoniae, Vibrio chlorae. Antifungal strain Candida albicans and Aspergillus niger using tube dilution method shows promising activity.

Keywords: 2-amino mercapto benzothiazole, anti-Inflammatory activity, antioxidant activity, and anti-microbial activity


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