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Abstract

ANTIDIABETIC EFFECT OF 50% HYDROETHANOLIC EXTRACT OF ARISTALOCHIA BRACTEOLATA LAM LEAVES IN STREPTOZOTOCIN- INDUCED DIABETIC RATS

K. Thangavelu* and V A Doss

ABSTRACT

The present work was aimed to evaluate the antidiabetic effect of 50% hydroethanolic extract of Aristalochia bracteolata Lam. leaves on 36 adult male albino Wistar rats weighing about 190-220 gms. Rats were divided into 6 groups of 6 rats in each. Group-I served as normal control while diabetes was induced in Group-II, III, IV, V and VI using Streptozotocin at a dose of 55 mg/kg bw by intraperitonial injection. After induction of diabetes Gtoup – II served as diabetic control. Group – VI rats were treated with 600 μg/kg bw/day of standard drug (Glibenclamide) while Group – III, IV and V rats were orally administred with 50% hydroethanolic leaf extract of Aristalochia bracteolata Lam. at the doses of 150, 300 and 450 mg/kg bw/day respectively for 28 days. To determine hypoglycemic effect of 50% hydroethanolic leaf extract of A. bracteolata Lam., blood and tissue biochemical parameters were assayed in normal, diabetic control and treated groups. Oral administration of 50% hydroethanolic extract of A. bracteolata Lam. leaves for 28 days exhibited a significant (p<0.05) antidiabetic effect similar to those produced by Glibenclamide at a dose of 600 μg/kg bw/day for 28 days. This study also revealed potent antioxidant effect of 50% hydroethanolic leaf extract of A. bracteolata Lam. 9 major compounds form the leaf extract were identified through GC-MS analysis.

Keywords: Leaf extract of Aristalochia bracteolata Lam., Streptozotocin (STZ), Glibenclamide (GB) and antidiabetic effect.


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