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Abstract

BIOLOGICAL EVALUATION OF SOME SYNTHESIZED BENZOTHIAZOLE DERIVATIVES AND THEIR CHARACTERIZATION

Vrushali Patil*, Ashish Asrondkar, Neha Mishra, Anil S. Bobade and A. S. Chowdhary

ABSTRACT

Substituted 1, 3-benzothiazole derivatives are an important class of heterocyclic compounds. The benzothiazole nucleus containing compounds in this work is been treated with hydrazine hydrate to form hydrazone derivative then it is treated with acetophenone further cyclisation is done by Vilsmeier-Haack reaction using DMF/POCl3 finally the intermediate is condensed by using substituted thiourea to form the desired products. All the synthesized compounds was confirmed by spectral analysis such as FT-IR, NMR Mass Spectrophotometer for structure confirmation and synthesized compounds were screened for various in-vitro biological activities such as anti-oxidant, anti-inflammatory, anti-microbial activity It was found that the synthesized compounds showed enhancing biological activity.

Keywords: Benzothiazole, Vilsmeier-Haack reaction, Anti-Oxidant, Anti-Inflammatory Anti-microbial etc.


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