WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

RP-HPLC METHOD DEVELOPMENT FOR THE QUANTITATIVE DETERMINATION OF DEXAMETHASONE IN HERBAL FORMULATION

Venkata Sairam K*, J C Thejaswini, M V Prudhvi Raju, R S Chandan,
B M Gurupadayya, K Mruthunjaya

ABSTRACT

A simple, sensitive method for the determination of dexamethasone used as an adulterant in herbal formulation was developed using reverse phase high performance liquid chromatographic method (RPHPLC). The analysis was performed on cyano (250 × 4.6mm, 5μm) column using 0.1% ortho phosphoric acid and acetonitrile (80: 20 v/v) as mobile phase at flow rate 1.2 mL/min. The eluents were monitored with UV detector at 242 nm. In the developed method dexamethasone elutes at a retention time of 8.8 min. The proposed method is having linearity in the concentration range from 5 to 60 μg/mL of dexamethasone. The present method was validated with respect to system suitability, linearity, precision, limit of detection (LOD) and limit of quantification (LOQ), accuracy (recovery) and robustness. The proposed method can be readily utilized for the detection of dexamethasone as an adulterant in herbal formulation.

Keywords: Dexamethasone, Herbal formulation, RP-HPLC.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More