QUANTITATIVE ESTIMATION OF HEAVY METALS IN RIVER WATER AND THEIR TOXICITY, HEMATOLOGY, GRAVIMETRIC, SERUM AND TISSUE BIOCHEMISTRY EFFECTS IN ALBINO RATS
Tathagat E Waghmare*, Hanumanthappa B Nayaka, Sanjeev Kumar C Banklgi and Asha Tukappa
ABSTRACT
The aim of present study is to investigate on the concentration of heavy
metals (Cu, Ni, Fe, Co, Mn, Cr and Zn) present in the water and their
effects on Toxicity, Hematology, Gravimetric and Serum biochemistry
of healthy albino rats. The results showed that 50% of toxicity and
there was significant difference (p<0.05) in the Red Blood Cell (RBC)
and White Blood Cell (WBC), It indicate the hemolytic anemia. This is
due to injurious effect of the toxic heavy metals of water. Where in
case of Gravimetric study the average weight reduced significantly
(p<0.05) in test rats when compared with control, indicating that, the
excess heavy metal water exposure to rats caused reduction in weight
of liver, heart, kidney and adrenal. The serum biochemistry studies of
protein, cholesterol, urea, and phospholipids were reduced in all the
groups studied. Thus, it can be concluded that heavy metals of water as serious consequences
on toxicity, hematology, Gravimetric, Tissue and serum biochemistry in rats and causes
hemolytic anemia which is attributed to the toxic effect of heavy metals of the water in the
experimental rats.
Keywords: Heavy metals, Hematology, Toxicity and Gravimetric.
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