Abstract

QUANTITATIVE ESTIMATION OF HEAVY METALS IN RIVER WATER AND THEIR TOXICITY, HEMATOLOGY, GRAVIMETRIC, SERUM AND TISSUE BIOCHEMISTRY EFFECTS IN ALBINO RATS

Tathagat E Waghmare*, Hanumanthappa B Nayaka, Sanjeev Kumar C Banklgi and Asha Tukappa

ABSTRACT

The aim of present study is to investigate on the concentration of heavy metals (Cu, Ni, Fe, Co, Mn, Cr and Zn) present in the water and their effects on Toxicity, Hematology, Gravimetric and Serum biochemistry of healthy albino rats. The results showed that 50% of toxicity and there was significant difference (p<0.05) in the Red Blood Cell (RBC) and White Blood Cell (WBC), It indicate the hemolytic anemia. This is due to injurious effect of the toxic heavy metals of water. Where in case of Gravimetric study the average weight reduced significantly (p<0.05) in test rats when compared with control, indicating that, the excess heavy metal water exposure to rats caused reduction in weight of liver, heart, kidney and adrenal. The serum biochemistry studies of protein, cholesterol, urea, and phospholipids were reduced in all the groups studied. Thus, it can be concluded that heavy metals of water as serious consequences on toxicity, hematology, Gravimetric, Tissue and serum biochemistry in rats and causes hemolytic anemia which is attributed to the toxic effect of heavy metals of the water in the experimental rats.

Keywords: Heavy metals, Hematology, Toxicity and Gravimetric.