WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

ANTI-ANXIETY- AND ANTIDEPRESSANT-LIKE EFFECTS OF THE COMBINATION OF 6-NITRO-2(1H)-QUINOXALINONE AND 2(1H)- QUINOXALINONE IN WISTAR RATS

Redouan NAKACHE*, Aboubaker ELHESSNI, Ali OUICHOU, Mohamed EL FAYDY, Inssaf BERKIKS, Youssef BAHBITI, Brahim LAKHRISSI, Bouchra BENAZZOUZ, Abdelhalem MESFIOUI

ABSTRACT

To augment the effect of classical anti-anxiety and/or antidepressant
drugs by combination therapy, which refers to the addition of drugs to
enhance their effects, reduce their dose with better efficacy and lower
side effects, has been a critical choice and an emerging treatment
strategy. In this study, the anti-anxiety and antidepressant potential
effect of intraperitoneal co-administration of 6-nitro-2(1H)-
quinoxalinone (NQu) and 2(1H)-quinoxalinone (Qu) in the open field
test (OFT), elevated plus maze (EPM) and forced swimming test
(FST), was evaluated. The combination of NQu (10mg/kg) and Qu (10
mg/kg) exhibited anti-anxiety-like potential synergistic effect in the
OFT, whereas, this combination caused no effect in the duration of
immobility in the FST. While 20 mg/kg of NQu and Qu separately
administered was ineffective in exhibiting the anti-anxiety-like effect in the OFT and EPM.
On the contrary, 20 mg/kg of Qu significantly decreased the duration of immobility in the
FST. By contrast, Diazepam (Dz) (1 mg/kg) was not influenced by the co-administration of
NQu/Qu (10 mg/kg). None of the drugs used in the present study had any effects on the
locomotor activity test at the doses applied. The results show that co-administration of NQu
and Qu exhibits a synergistic effect and that no potential interaction occurred by association of NQu/Qu and Dz. Taken together, these results show that reducing the dose of tested molecules does not remove their anxiolytic effect when combined suggesting the existence of a synergistic interaction between the two molecules.

Keywords: anxiety, depression, synergistic effect, diazepam, 6-nitro-2(1H)-quinoxalinone, 2(1H)-quinoxalinone, wistar rat, OFT, EPM, FST.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More