WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

AMELIORATIVE EFFECT OF N-ACETYL-L-CYSTEINE ON SODIUM DICHROMATE-INDUCED ALTERATIONS OF HAEMATOBIOCHEMICAL PARAMETERS IN RATS

S. B. Mada*, M. M. Abarshi and O. E. Gabriel

ABSTRACT

Protective effect of antioxidant N-acetyl-L-cysteine (NAC) on sodium dichromate induced-haemato-biochemical alterations was study. Rats were divided into four treatment groups of ten rats each. Group 1 received DMSO (2 mL/ kg) and served as normal control. Group 2 were administered with sodium dichromate (10 mg/kg) in 0.2 mL deionized water and served as negative control. Group 3 and 4 were administered with sodium dichromate (10 mg/kg) in 0.2 mL deionized water each and NAC (25 and 50 mg/kg) in 0.2 mL DMSO respectively. The treatment was carried out daily for 12 weeks. Results revealed NAC administration significantly (P < 0.05) reversed the hepatic damage in a dose-dependent manner when compared to nontreated group. Interestingly, our results showed administration of NAC significantly (P < 0.05) increase SOD and CAT activities along with elevation of GSH and decrease MDA levels in dose-dependent manner when compared to non-treated group. Moreover, NAC administration reversed the increase in urea and creatinine levels and restored haematological parameters when compared to non-treated group. The present study, suggests that NAC possess protective effect against sodium dichromate induced-alterations of haematobiochemical parameters in rats.

Keywords: Sodium dichromate; N-acetyl-L-cysteine; oxidative damage; haematological parameter


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More