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            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
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*Dr. Raghad DH Abdul Jalill1; Dr.Salih A. Al-Bakri2; Dr. Shatha Ali Shafiq1; Dr. Amer T. Tawfeeq3

1College of Science AL- Mustansiryia University; Iraq/ Baghdad.
2Environmental Research Centre – University of Technology, Iraq/ Baghdad.
3The Iraqi Center for Cancer and Medical Genetic Researches– University of Al-Mustansiryia. Iraq/ Baghdad.


Pure silver colloids nanoparticles were synthesized using laser ablation in liquid environment. A transmission electron microscope (TEM) was employed to take the electron micrographs of the solutions.The UV– VIS absorption spectra of Ag nanoparticles exhibit a characteristic peak around 400 nm, indicating the formation of Ag nanocolloids. The Ag colloids nanoparticles have an average diameter of 17 nm were produced. Amplitude parameters was: Sa (Roughness Average) 4.98 nm, Sq (Root Mean Square) 6.53 nm, Ss (Surface Skewness) -0.0738, Sku (Surface kurtosis) 3.55, Sy (Peak-Peak) 43.2 nm, Sz (Ten Point Height) 42.4 nm.The concentration of produced Ag nanoparticles of 100 μg/ml was estimated by AAS. This study was carried out to evaluate the cytotoxic effects of silver nanoparticles and silver non- nanoparticles on L20B cell line.There were non-significance changing in cell viability treating with all concentrations of silver nanoparticles. But the higher concentrations of silver non-nanoparticles (10 μg/ml) reduced cell growth significantly. The inhibitory rate was: 40.54%. All lower concentrations (0.01 ng/ml-1 μg/ml) show non-significance changing on cell viability. There were significant differences between means of cell viability treating with (10 μg/ml)silver nanoparticles compared with silver non- nanoparticles concentrations.It was more reduction and cytological study of higher concentrationshowed that there were the cells were very small with vacuolated cytoplasm with few dead cells and pyknosis with cellular debris. There was no important difference in morphological changes between cell lines exposed to (0.01 ng/ml - 1 μg/ml) of silver non- nanoparticles and control negative.The cytological study of silver nanoparticles showed no cytotoxic effect of low concentration (0.01 ng/ml), while at a medium concentration (0.1 ng/ml - 0.1 μg/ml), formation of multinucleated giant cells, few dead cells and earlier stages of cytolysis could be seen. At higher concentration (1 μg/ml - 10 μg/ml), cytolysis appeared to be more severe.The results suggest that silver colloids nanoparticles, synthesized by laser ablation in liquid environment, showed less cytotoxic effect on L20B cell linecompared with silver non- nanoparticles.


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