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Abstract

DESMODIUMGANGETICUM (L) TRIGGERS INOTROPIC AND ELECTROPHYSIOLOGICAL CHANGES IN CARDIAC TISSUE THROUGH INACTIVATION OF THE NA+, K+-ATPASE SIGNALING CASCADE - AN IN – VITRO AND IN- VIVO CORRELATIONS

Mohamed Shabi M,*Vasudeva Rao Avupati, Rameashkannan and Mani P

ABSTRACT

Background: Desmodiumgangeticum(L) (DG) an herb which belongs to the family Fabaceaeis a perennial shrub widely distributed in tropical and sub-tropical habitats and particularly abundant in India. DG is widely used for the treatment of cardiovascular disease in the Indian System of Medicines. The petroleum ether root extract of DG was evaluated for its cardio-protective activity using isolated frog´s heart perfusion method and to assess the electrocardiographic changes in rats. Method: Thein-vitro positive inotropic and chronotropic activities in isolated frog heart were recorded using perfusion apparatus bykymographical techniques. The in-vivo method, rats were treated with Desmodiumgangeticum (500mg·kg–1, p.o) for a period of 30 days. At the end of experiment, electrocardiographic changes were monitored from control and experimental groups. Result: The petroleum ether root extract of Desmodiumgangeticum showed a dose dependent positive inotropic and negative chronotropic action on isolated frog heart. The pharmacological effect may be due to theinactivation of the Na+, K+- ATPase signaling cascade.In addition, Desmodiumgangeticum administered rats showed a significant alteration in electrocardiograph pattern changes when compared to control groups. Moreover, GC- MS of DG root extract confirm the presence of bio-molecules that can stimulate the release of calcium in heart and protect from oxidative stress in heart. Conclusion: In present study, we can conclude that root extract of Desmodiumgangeticum can protect the myocardium against the cardiac depression by blocking Na+, K+-ATPase signaling cascade similar to the action of digoxin. The effect of the Desmodiumgangeticumextract may be presence of glycosides.

Keywords: DG, Positive inotropic, Electrocardiograph, GC- MS, heart.


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