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Abstract

DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF LORNOXICAM AND PARACETAMOL IN PHARMACEUTICAL DOSAGE FORM

Vyas Janki T.*, Dr. Zarna R. Dedania, Dr. S.M.Vijyendraswamy, Mrs. Henal Chorawala and Ms. Jasmina Surati.

ABSTRACT

A novel analytical UV spectrophotometric method has been developed in presented research work for simultaneous estimation of Lornoxicam and Paracetamol in pharmaceutical dosage form. In the proposed Absorption correction method, linearity range was observed in the concentration range of 1-6 μg/ml for Lornoxicam and 12-32 μg/ml for Paracetamol with r2 values 0.9990 and 0.9987 respectively. The wavelengths selected were 376 nm and 257nm, for Lornoxicam and Paracetamol in 0.1 N Sodium Hydroxide respectively.. The limit of detection for Lornoxicam and Paracetamol were found to be 0.018μg/ml and 0.027μg/ml respectively. Limit of quantification were found to be 0.055μg/ml and 0.084μg/ml for Lornoxicam and Paracetamol respectively. Validation of the proposed method was carried out for its accuracy and precision according to ICH guidelines. The accuracy of the method was checked by recovery experiment performed at three different levels of 80%, 100% and 120 %. The percentage recoveries of Lornoxicam and Paracetamol were found to be in the range of 100.24-100.95% and 99.25- 99.95% respectively. The low values of % relative standard deviation (RSD) are indicative of the accuracy and reproducibility of the method. The precision of the method was studied as an intra-day, inter-day variations and repeatability. The % RSD value less than 2 indicate that the method is precise. The method was found to be rapid, simple, accurate and precise.

Keywords: Lornoxicam, Paracetamol, Absorption correction UV spectrophotometric method, validation.


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