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Abstract

ALTERATIONS IN BIOCHEMICAL INDICES DURING REPEATED ORAL ADMINISTRATION OF MOLYBDENUM ALONE AND IN CONJUNCTION WITH COPPER SULFATE IN GOATS

Kusum, Rajinder Raina*, Pawan Kumar Verma and Imtiyaz Ahamad

ABSTRACT

Molybdenum is an essential trace element existing in the animal body in varying concentrations in different tissues and its toxicity is a serious problem in many parts of the globe. To access the alterations in the various biochemical indices during subacute toxicity of molybdenum and its amelioration by concurrent exposure with copper sulphate in goats. In the present study, ammonium molybdate at 20 mg/kg/day alone and in conjunction with copper sulphate (II), pentahydrate at 7.9 mg/kg/day was administered orally for 30 consecutive days in healthy goats of group I and II respectively. In group I, significant (P<0.05) alterations in plasma proteins profile, blood urea nitrogen and creatinine were observed on different days of exposure from pre-exposure values. However, no significant changes were observed in plasma calcium, phosphorous, magnesium, sodium and potassium on different days of exposure of ammonium molybdate. However, concurrent exposure with the copper sulphate (Group II) no significant changes were observed on different biochemical indices. Observation from the present study suggested that ammonium molybdate alone produced significant alterations in some biochemical indices and concurrent administration with copper sulphate reversed the alterations induced from the ammonium molybdate exposure.

Keywords: Copper sulphate; biochemical indices; goats; molybdenum; subacute.


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