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Abstract

THE EFFECT OF pH ON THE ANTIBIOTIC ACTIVITY OF 2, 3 DIHYDROXYBENZOIC ACID (2, 3 DHB); AN ANTIBIOTIC ISOLATED FROM THE FRUITS OF FLACOURTIA INERMIS AND ITS PROSPECTS IN THE TREATMENT OF HELICOBACTER PYLORI (H.PYLORI).

Shibu George*, Suja N and Benny P J

ABSTRACT

2, 3 Dihydroxybenzoic acid, isolated from the fruits of Flacourtia inermis is an effective antibiotic against various microorganisms. Helicobacter pylori is a pathogenic bacterium of the gastric mucosa. Presently, there is no single effective antibiotic against it; lots of scientific searches are going on to develop a potent antibiotic with fewer side effects. In this study, an attempt was made to evaluate the effect of pH; both acidic and alkaline on the antibacterial activity of 2, 3 DHB, so as to suggest this compound for further studies in H.pylori treatment. For the study, the pH of 2, 3 DHB was modified to 1 and 10 by treatment with concentrated HCl and NaOH respectively. The antibacterial activity of the modified compound was tested by disc diffusion method against standard strains. This is based on the fact that the antibiotics that are used against the common bacterial diseases are being used as a remedy against H.pylori. The results of the study revealed that the 2, 3 DHB in pH 1 was highly active against all the tested strains such as Staphylococcus aureus, Pseudomonas aeruginosa, Serratia marcescens, Escherichia coli and Klebsiella pneumoniae. The activity was slightly higher than that obtained against unmodified, natural 2, 3 DHB. However, the activity of 2, 3 DHB in pH 10 was ineffective to inhibit the growth of tested bacteria. As the compound 2, 3 DHB was inactive in alkaline medium, the oral administration of 2, 3 DHB may not affect the alkaline intestinal fauna. This is one of the major advantages of 2, 3 DHB than any other antibiotics. 2, 3 DHB is also an effective antioxidant and its toxicity has not yet been reported. The study concluded that the antibiotic 2, 3 DHB in HCl is highly active. Therefore, it can be recommended for further studies in H.pylori treatment both in vitro and in vivo.

Keywords: 2, 3 Dihydroxybenzoic acid, 2,3 DHB, Flacourtia inermis, antibiotic, Helicobacter pylori, H.pylori.


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