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Abstract

PROTECTIVE EFFECT OF CURCUMIN ON HEMATOLOGICAL ALTERATIONS INDUCED BY REPEATED ADMINISTRATION OF FLUORIDE AND ?-CYHALOTHRIN ALONE AND IN COMBINATION IN WISTAR RATS

Imtiyaz Ahmad, Rajinder Raina*, Pawan Kumar Verma and Sandeep Pandita

ABSTRACT

Present study was aimed to investigate protective effect of curcumin on oral exposure of λ-cyhalothrin (LCT) and fluoride (F) on haematological parameters in wistar rats. Forty eight rats were divided into 8 groups with 6 rats in each. Animals in the Group I and II served as control and received only normal tap water and curcumin (100mg/kg, BW) respectively. The animals of Group III and IV were provided drinking water containing F (10 ppm) and LCT at the dose rate of 10 mg/kg BW through oral gavage respectively. Group V received both the toxicants simultaneously. The animals of group VI were treated with curcumin and provided water containing F and group VII received curcumin along with LCT. Group VIII received curcumin and both F in their drinking water and LCT daily for 14 days. Oral administration of F or LCT alone for 14 days didn’t significantly alter the haemoglobin Hb, packed cell volume (PCV), total erythrocyte count (TEC) levels but coexposure of toxicants for 14 days significantly (P<0.05) alters hematological parameters. Coexposure of toxicants also significantly (P<0.05) induced leucocytosis as compared to control animals. Treatments with curcumin protect the hematological alterations induced by repeated oral exposure of F and LCT for 14 days.

Keywords: ?-cyhalothrin; haematological parameters; fluoride, curcumin.


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