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Abstract

EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF SEA GREEN ALGAE OF CHAETOMORPHA ANTENNINA

N. Jaya Raju*, Rama Rao Nadendla, Ganga Rao Battu

ABSTRACT

The objective of this study was to evaluate the anti-inflammatory
activity of methanolic extract of Chaetomorpha antennina.
Chaetomorpha antennina is green algal species found in the sea. The
anti-inflammatory activity was evaluated by using carrageenan induced
hind paw edema model. The methanolic extract of Chaetomorpha
antennina at the doses of 50, 100 and 200 mg/kg b.w., produced dose
dependent significant reduction (p<0.05–0.001) in carrageenaninduced
rat maximal paw edema by 62.21 ± 1.65, 67.23 ± 0.57, 69.96
± 0.74 compare to the standard drug Diclofenac sodium at dose
50mg/kg reduced edema by 72.41 ± 1.49 respectively and the total
(AUC) paw edema by 65.18 1.01, 69.42  2.93 and 72.82  2.15 compare to Diclofenac
sodium at dose 50mg/kg reduced total (AUC) paw edema by 75.35  2.87 respectively. The
results suggested that the Chaetomorpha antennina possessing in vivo anti-inflammatory
activity.

Keywords: Chaetomorpha antennina, carrageenan, anti-inflammatory activity, Diclofenac sodium.


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