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Abboju. Prasad*, K.Nirmala, K.Keerthi and D.Sathish


In the present research work gastro retentive floating formulation of Amlodipine besylate by using various hydrophilic polymers were developed. Initially analytical method development was done for the drug molecule. Absorption maxima was determined based on that calibration curve was developed by using different concentrations. Gas generating agent sodium bicarbonate concentration was optimized. Then the formulation was developed by using different concentrations of polymers of various grades of HPMC and Guar gum as polymeric substances. The formulation blend was subjected to various preformualation studies, flow properties and all the formulations were found to be good indicating that the powder blend has good flow properties. Among all the formulations the formulations HPMC K100 as polymer were retarded the drug release up to desired time period i.e., 12 hours in the concentration of 100 mg(F5 Formulation, 99.33% Drug release). Where as in low concentrations the polymer was unable to produce the desired action. The formulations prepared with HPMC K15 were also retarded the drug release for more than 6 hours. Hence they were not considered. The optimized formulation dissolution data was subjected to release kinetics, from the release kinetics data it was evident that the formulation followed zero order mechanism of drug release.

Keywords: Amlodipine besylate, HPMC polymers, Floating tablets.

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