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Abstract

A PRE-CLINICAL COMPARATIVE STUDY OF THE ANTI GASTRIC ACID-SECRETORY AND ANTI-ULCEROGENIC EFFECT OF ROXATIDINE AND RABEPRAZOLE USING A RAT MODEL.

Mehre Darakhshan Mehdi, Somnath Maity, Ranjita Santra, Nandita Biswas, Manisha Das and *Prithwijit Banerjee

ABSTRACT

Background & objectives: NSAIDS induced gastric ulcer is very common nowadays; a number of drugs are used to prevent NSAIDS used ulcer. In this study we evaluated the antiulcerogenic effect i.e prevention of Aspirin induced ulcer and antisecretory effect of Roxatidine, the second generation H2 receptor antagonist and one of the widely used proton pump inhibitor Rabeprazole in wistar rats. Methods: The antisecretory effect of both drug and control is compared by pyloric ligation method. Free and total titrable acid is measured and compared. The antiulcerogenic effect is compared by aspirin (200mg/kg) induced gastric ulcer in wistar rats. Ulcer index of both the drug and control is determined and compared. Result: In our study, Rabeprazole (20 mg/kg) was more effective than roxatidine (5mg/kg) in reducing free and total titrable acids and in reduction of ulcer (p<0.05). Both the drugs were superior to that of control (p<0.001). Interpretation & conclusion: Based on our findings, we presume that the anti-secretary and antiulcerogenic (i.e Prevention of NSAIDS induced gastric ulcer) properties of Rabeprazole is better than that of roxatidine in animal model.

Keywords: Aspirin; NSAIDS, Rabeprazole; Roxatidine, Ulcer index.


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