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Abstract

AN EFFICIENT SYNTHESIS OF IMINO PYRAZOLO PYRIDO [1,2- a]PYRIMIDINES AND THEIR ANTIMICROBIAL ACTIVITY

Avinash V. Pawde, Prashant N. Ubale and Sambhaji P. Vartale*

ABSTRACT

New pyrazolo pyrido pyrimidine derivatives have been synthesized by condensation of 7-bromo-3-cyano-4-imino-2-methylthio-4H-pyrido [1, 2-a]pyrimidines (3) with hydrazine and its various derivatives. The chemical structure of the product was proved on the basis of their spectal IR, 1H-NMR, 13C-NMR, Mass and analytical studies. All the newly synthesized compounds have been screened for antimicrobial activity.

Keywords: Bis (methylthio) methylene malononitrile, Pyrazolopyrido pyrimidine, N,N-dimethyl formamide, anhydrous potassium carbonate.


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