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Abstract

EFFECT OF PROTEIN DIET SUPPLEMENTATION IN HUMORAL, CELL MEDIATED IMMUNE RESPONSE AND ANTIOXIDANT STATUS IN PLASMODIUM YOELII INFECTED BLOOD OF SWISS MICE (MUS MUSCULUS)

Soumitra Banerjee*, Nirmal Kumar Pradhan, Rudra Prasanna Banerjee and Parantap Sarkar

ABSTRACT

Plasmodium yoelii like many other parasitic protozoans is deficient of having the advantage of the de novo pathway for purine biosynthesis and starkly acts upon the salvage pathway. It is the causative agent of Malaria. A new approach can be designed by understanding the regulatory mechanism of immune response during the Plasmodium infection. Plasmodium-specific CD4+ αβ T cells and antibody are mostly important for the immune response during the infection. It has been reported that NK cell-derived IFN-γ that contributes to the early control of Plasmodium chabaudi and Plasmodium yoelii infections. Protein availability for the metabolic processes, the major reservoir in the lean body mass is represented by muscle. During this disease significant reductions in lean tissue or by extension, the muscle mass will attenuate the immunological response, as well as reduce physical activity. The provision of protein in the diet could meet some of the requirements of amino acids for the immune and restorative response. The influence of infection on protein nutritional status has been extensively reviewed in earlier stage of malaria.

Keywords: CD4+ ?? T cells, Plasmodium yoelii, NK cell, Protein diet.


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