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Abstract

A REVIEW: OSMOTIC DRUG DELIVERY SYSTEM

Shreya V. Udawant*, Sheetal B.Gondkar, Ravindranath B. Saudagar

ABSTRACT

Conventional oral drug delivery systems supply continues release of drug, which cannot release of the drug and effective concentration at the target site. Drug can be delivered in a controlled manner over a long period of time by the process of osmosis. Osmotic devices are the most promising technique for controlled dug delivery. Osmotic drug delivery system is one among the controlled drug delivery employed orally and also as an implantable devices. These systems utilize osmosis as the major driving force for drug release. Various patents available for osmotic drug delivery system like Rose-Nelson pump, Higuchi leeper pump, Higuchi Theeuwes pump, Elementary Osmotic pump etc. Various techniques available for preparation of Osmotic Drug Delivery System include Push pull osmotic pump, Osmotic brusting osmotic pump, Liquid oral osmotic system, Sandwiched osmotic tablets, Delayed delivery osmotic device, Monolithic osmotic system and Controlled porosity osmotic pump. Osmotic drug delivery devices are composed of an osmotically active drug core, which is surrounded by a rate controlling membrane. Osmotic drug delivery systems differ from diffusion based systems in that the delivery of the active agents is driven by an osmotic gradient rather than the concentration of drug in the device.

Keywords: Osmotic drug delivery, Osmosis, Osmotic gradient, various techniques for osmotic drug delivery.


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