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Abstract

REVERSE PHASE LIQUID CHROMATOGRAPHY DETERMINATION OF ATORVASTATIN CALCIUM AND PIOGLITAZONE HYDROCHLORIDE IN TABLET DOSAGE FORM

Hiral J. Panchal1*; Bhanubhai N. Suhagia2

1Arihant School of Pharmacy & Bio-Research Institute, Uvarsad Square, Adalaj, Gandhinagar, Gujarat, India.
2Department of Pharmaceutical Chemistry, Faculty of Pharmacy, D. D. University, Nadiad, Gujarat, India.

ABSTRACT

A simple and sensitive reverse phase liquid chromatographic method for estimation of atorvastatin calcium and pioglitazone hydrochloride in tablet dosage form has been established and validated. The LC separation was achieved on a Phenomenex Luna C18 column (250mm, 4.6mm i.d., 5μm), in the isocratic mode using 0.65M ammonium acetate buffer: acetonitrile (50: 50 v/v), pH 6.9 0.05, as the mobile phase at a flow rate of 1.2 mL/min. The retention times were about 4.64 and 6.39 min for atorvastatin calcium and pioglitazone hydrochloride, respectively. Quantification was carried out at 258 nm over the concentration range of 0.5-3 μg/mL for each drug, with mean recoveries of 99.51 0.21 % and 100.05 0.27 % for atorvastatin calcium and pioglitazone hydrochloride, respectively. The method was validated for specificity, linearity, accuracy, precision and robustness. The method is found to be simple, specific, sensitive accurate and precise with potential application in pharmaceutical analysis.

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