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Abstract

SYNTHESIS DOCKING AND QSAR STUDIES OF QUINOLINE DERIVATIVES

B. Mayuri, N.Pramod*, R. Nagendra Babu, S.Chandra Prakash, R.J. Naveen Kumar, K. Madhuri

ABSTRACT

Five novel quinoline derivatives (BPM-1 to BPM-5) are synthesized.
The synthetic scheme of quinolines derivative involves the reaction
between 2-methoxy acetanilide with Vilsmayer Hack reagent (POCl3,
DMF).The formed 2-chloro-3-formyl-8-methoxy-quinolines. Further
treated with sodium sulfide flakes resulted in to 3-formyl-8-methoxy 2-
thio quinolines. Finally fused with various aryl amines to give 5-novel
quinoline derivatives. Docking and Qsar studies where performed for
designed compounds using Autodock 4.2 version. The results of
Docking and Qsar studies reveled that both compounds BPM-1 and
BPM-2 possess similar antibacterial activity.

Keywords: Quinoline derivatives, Docking, QSAR, antibacterial activities.


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