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Abstract

ANTIBACTERIAL AND ANTI-INflAMMATORY ACTIVITIES OF CALENDULA OFFICINALIS GROWING IN IRAQ

Rehab S. Ramadhan*, Zinah F. Hussein and Rana K. Dulaimi

ABSTRACT

This study was designed to evaluated antimicrobial activity of Calendula officinalis aqueous extract against some pathogenic microorganisms. So that, the aqueous extract of Calendula officinalis was screened for its anti-microbial activity using the plate agar diffusion method. It was tested against four bacteria species; two Gram-positive bacteria (Bacillus subtilis, and Staphylococcus aureus) and two Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa). The susceptibility of these different bacterial species toward the extracts of this plant was compared with each other and with selected antibiotic (streptomycin) used as positive control. Result showed that aqueous extract of Calendula officinalis had antibacterial activity against gram positive bacteria. The effect of Calendula officinalis was studied on male albino mice that included two parts .the first part was the affect of the extract on organ physiology like liver and kidney. The second part was the effect of the extract on the bacterial infection and wound healing. The study was performed by designing an experiment in which four groups of mice were set, every groups is of three mice. The first group was control, the second group was administrated with extract oral mouth for 10 days in concentration of 100mg/kg, the third one was administrated with 75 mg/kg, and the fourth group was feed with 25 mg /kg of the extract. After 10 days, mice were killed and put for autopsy histology slides were made from kidney and liver and compared with control group. No change was observed among studied slides which may indicate that the extract has no toxic effect on organs.The other part of the study was the effect of aqueous extract on bacterial infection and wound healing. Two groups of mice three in each one were studied. the first one is control that was wounded on wounds were infected by staphylococcus aureus and left for normal healing, while the other group was treated by the extract after infecting wounds and contaminating them by staphylococcus aureus. Our results showed an accelerated healing in wounds of extract treated group compared with control.

Keywords: (Antibacterial, Anti-Inflammatory, Phytochemical, Histopathology, Calendula officinalis).


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