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Abstract

BREAST CARCINOMA IN WOMEN 40 YEARS OF AGE OR YOUNGER: EPIDEMIOLOGICAL PROFILE IN SERIES OF 135 CASES FROM EASTERN ALGERIA

Henouda Sarra*, Bensalem Assia and Rouabah Leila

ABSTRACT

Background: Actually, breast cancer constitutes one of the most
health problems in Algeria and the leading cause of death among
Algerian women. Breast cancer in young women is a rare form, but it
has an aggressive behavior associated with a poor prognosis. Aims:
this study focuses to report breast cancer phenotype in Algerian young
women. Material and methods: in order to better understand the
determinants and tumor biology that may explain earlier onset and
aggressive breast cancer characteristics in Algeria from December
2011 to July 2014, 135 patients aged 40 years and under diagnosed
with breast cancer were included in the study. Results: Of the 135
patients recorded, 65.9% patients were aged between 36-40 years. The
mean age was 36.29 years. A significantly higher proportion of women
were overweight or obese (62.9%). 75.6% of patients had full-term pregnancy. 29.6% of
breast cancers were diagnosed during pregnancy or after childbirth. Positive breast cancer
family history was found in 34.1%. In 87.4% of cases the revealing sign was breast mass.
Stage II and III associated with axillary lymph nodes involvement, higher pathological grade
and hormone receptor positive were predominant. Neo-adjuvant was administered to 28.8%.
74.1% of patients underwent radical mastectomy using Patey technique with complete
axillary dissection. Distant metastases at diagnosis were seen in 13.3%. The mean clinical
tumor size was 4.80 cm. 71.1% of tumors were invasive ductal carcinoma. Conclusion: early-onset Algerian breast cancer is more likely to present at an advanced stage with poor prognosis.

Keywords: Algeria, breast cancer, young women, prognosis, advanced.


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